The Diosgenin Derivatives' Synthesis And Biogical Activities

It was testified that diosgenin could relax the guinea pig isolated trachea and the effect was superior to the same activity of imperialine,an M receptor antagonist.This result was reported firstly.Hereby,it implied that biological activity of diosgenin might be intervented by M receptor,which provided a new scene for clarifying disgenin's founction route.Seven diosgenin derivatives were designed and synthesized,and six of them were new compounds.Their biological activities were tested. The biological activity of 3β-p-methylbenzoatediosgenin was better ,the 3β-valeryldiosgenin's was equal ,and the others' were decreasing, compared with diosgenin.This result exhibited the orderliness.The structure of these compounds were identified by spectral data.