Synthesis Of Ibutilide Fumarate

Objective Explores a new synthetic method of preparing Ibutilide Fumarate.Methods The synthesis cost is high with basing on Ibutilide Fumarate literature synthetic method, because of involving several quite expensive raw materials. They are N,N'-dicyclohexylcarbodiimide, 1-hydroxybenzothriazole and the raw n-heptylamine of preparing ethylheptylamine .Moreover time the impurity has produces in preparating amide .It is difficult to separate the impurity.After being purified many times the quite pure product will be obtained. This article propose the outset raw material with 2- pyrrolidone,The Ibutilide Fumarate was synthesized from N-alkylation, the hydrolization, acylation, Friedel-Crafts reaction , reduction and salification ,with the new synthetic method. This synthetic method has not until seen the literature registration. This synthetic method synthesized three new compounds, and their structure performs with the 1HNMR spectrum and the infrared spectrum .the quality of Ibutilide Fumarate conforms to proclaim the standard after 1HNMR spectrum, infrared spectrum, HPLC,and so on.Results This synthetic method raw material is easy, craft route shorter, always receiving rate is high, easy industrialization production.