The Clinic Observation And Experimental Study Of Treatment Of Vascular Dementia With Regulation Of Pathway Of Qi

OBJECTIVES: To investigate the effect and mechanism of treatment of vascular dementia with regulation of pathway of Qi.METHODS:80 patients with vascular dementia (VaD) were divided into treatment group and control group in random.Mini-Mental State Examination(MMSE) is to show the ability of cognition, orientation ,memory, calculation language, visual space, operation ect. Activities of daily living(ADL) is to observe the abilities of daily living. The Active avoidance reaction(AAR) is to investigate the degree of dementia. Measurements: MMSE score ,Nimodipine method formula, observations of the change of Hemorheology,transcranial dopplar. 20 female Sprague Dawley Rats are divided into 4 groups,experimental groups a and b,model groups a and b,each group 5 rats. Another 8 rats as pseudosurgery groups a and b,each group 4 rats. Observation of cortical expression of OD value and AAR ratio in the cell of positive immumne reaction to 1GF-I and 1GF-IR. RESULT: The treatment group had significantly high MMSE score than the control group(p<0.05), lower ADL and CDR score(p<0.05), more effective (P<0.01) and improvement in Hemorheology and TCD(P<0.05).The experimental study show that the treatment group had increased the ischemic cortical expression of OD value and AAR ratio (P＜0.05) in the cell of positive immumne reaction to IGF-I and 1GF-IR. CONCLUSION: These results suggest that using the method of regulation of the pathway of Qi can relieve the dementia symptoms ,improve the brain circulation, induce the IGF-I and IGF-1R expression of neuron in the ischemic area.