The Clinical Research Of Surgical Treatment Of Gastrointestinal Stromal Tumors

Research objectiveTo evaluate the clinical diagnosis and treatment of gastrointestinal stromal tumors(GIST).Clinical material and methodsThe clinical data of patients of GIST admitted into surgical department from Jan 2001 to Dem 2006 were retrospectively analyzed.There were 32 cases enrolled,21 patients undergone tumor resection,11 patients only did partial resecti,on or biopsy.Imatinib Mesylate was administered to three patients and achieved partial relief,one of the three undergone tumor resection.The groups of different risk were analyzed by the outcome of follow-up.ResultsPathological examinationsAll the cases undergone Pathological examinations,including CD117 and CD34 immunohistochemical staining.According to the Fretcher classification,all the patients were of very low risk,of low risk,of intermediate risk,of high risk. SubsistenceThirty-one patients were followed up,12 out of 31 postoperative patients died of metastasis and recurrence,7 out of the 21 patients who undergone total tumor resection suffered from recurrence,relapse rate is 33.3%,and median time of relapse was 7 months. Conclusion1.Cellular morphology and immunohistochemical staining are necessary for the diagnosis of GIST.2.Spiral CT can be aid to preoperative diagnosis of GIST.3.Flether classification is useful guide for clinical and prognosis prediction.4.Surgical resection of GIST after Treatment with Imatinib provides a new treatment of GIST.