| Objective: To observe the effect of radiotherapy and chemoradiotherapy in patients with esophageal cancer and analyze the associated factors of surviving with esophageal patients. Methods: 60 cases were retrospectively analyzed in the study. They were divided into two groups according to the treatment methods, radiotherapy (RT) group and chemoraidiotherapy (CRT) group. The group CRT was divided into concurrent chemoraidiotherapy (CCRT) group and sequence chemoraidiotherapy (SCRT) group. The group RT and group CRT all use 6mvX line conventional therapy, common fraction 200Gy/f, DT 60 to 70Gy, Group CRT combine the chemotherapy concurrent or after radiotherapy. Kaplan-Miere survival curve, Log Rank model to be used and Cox regression model were applied to evaluate the overall survive rate and the prognostic factors respectively. Results: (1) The 1.2,3,5year survival rate of the group CRT and the group RT are 73.30%, 46.70%, 16.67%, 0% and 60.30%, 16.67%, 6.67%, 0% respectively, 2 year survival of group CRT is better than group RT (P<0.05), but 1,3,5 year survival between RT and CRT are not significantly different. (2) The 1, 2, 3 year survival rate of the group SCRT and CCRT are 88.89%, 55.55%, 22.22% and 84.21%, 47.37%, 15.79% respectively. 1, 2, 3 year survival between two groups is not different (P<0.05). (3) The short-term side-effect is more serious, the patients could bear. (4) The prognosis of the esophageal carcinoma is closely associated with treatment methods and clinical stage. The treatment method is good prognostic factor while the clinical stage is poor prognostic factors. Conclusion: Chemotherapy combined with radiotherapy for advanced esophageal cancer improved the survival. Chemoradiotherapy is an effective treatment for advanced esophageal carcinoma, diagnosis and treatment in early stage are especially important.
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