Combined Monitoring For Predicting Perinatal Prognosis In Patients With Intrahepatic Cholestasis In Pregnancy

Objective: To study the value of antepartum Combined monitoring for perinatal prognosis with intrahepatic cholestasis of pregnancy(ICP). Methods: With fetal umbilical artery Doppler velocity and NST (non—stress test) , cholyglycine(CG), we inspected perinatal fetus results of 53 ICP puerpera ( ICP group ) and 46 normal puerpera (control group ) from January to December in 2006. Result: Intrauterine asphyxia, amniotic fluid contamination and low birth weight incidence in ICP group are apparently higher than control group(P<0.05); difference of asphyxia neonatorum and premature labor incidence have little significance. unfavourable prognosis incidence of NST , S/D outcome disorder group in ICP team is apparently higher than outcome disorder group in control team ( P < 0. 05 ); intrauterine asphyxia incidence is apparently higher (P <0. 05) , there is no significant difference in asphyxia neonatorum , low birth weight ratio son , premature labor incidence among the two groups. (P>0. 05 ). umbilical artery S / D value in ICP group correlate to sera bile acid level positively (P < 0.05) and has negative correlation with Neonate Apgar grade , S / D value has significant difference with 1 minute grade (P < 0.05) , has no apparent difference with 5minute grade (P > 0.05). Conclusion : By monitoring survey in gestational period , we find ICP has more opptunities to result in intrauterine asphyxia , amniotic fluid contamination and low birth weight ratio son. NST , umbilical artery S/D Cost have some meaning in forecasting ICP perinatal prognoses .