The Study Of RXRmRNA And MDRmRNA Expression In Psoriatic Lesion

Objective:To investigate whether the multudrug resistance relates to the expression of RXRmRNA and MDRmRNA in psoriatic lesion.Methods:groups:15 cases of normal skin,lesional skin of 18 cases of newly diagnosis psoriatic patients,23cases of relapsed patients;the technology of in situ hybridization was used to detect the expression of RXRmRNA and MDRmRNA.Results:①The positive RXRmRNA and MDRmRNA expression were observed in most keratinocytes except stratum comeum,especially in the upper layers.From the upper to the lower layers the reactivities were decreasing by degrees.②There were significantly stronger expression of RXRmRNA in the normal control skin than that in lesional psoriatic subjects,and that of newly diagnosis stronger that of relapsed patients(P＜0.05);The grade of MDRmRNA in the normal control skin was lower than that in lesional psoriatic subjects,and that of newly diagnosis was lower than that of relapsed patients(P＜0.05);③There were no correlation between the expression of RXRmRNA and MDRmRNA.Conclusions:Decreased expression of RXRmRNA and increased expression of MDRmRNA might be some of the factors of up-regulating drug resistance.But there were no relationship between these two factors.