The Clinical Study Of Plasma Thrombin Antithrombin Ⅲ Complex, Von Willebrand Factor, D-dimer In Patients With Acute Leukemia

【Objective】To measure the levels of plasma thrombin antithrombinⅢcomplex(TAT), von willebrand factor(VWF),D-dimer(DD)in different phrases of patients with acute leukemia,and to explore their significance in the diagnosis and clinical therapy of acute leukemia.【Methods】Fifty acute leukemia patients and thirty health adult were selected into the study.The levels of plasma thrombin antithrombinⅢcomplex,von willebrand factor and d-dimer were measured by enzyme linked immunosorbent assay(ELISA).The acute leukemia patients were measured in different phrases. Meanwhile,we contracted Acute Promyeloblastic Leukemia(APL)with the other type of acute leukemia.【Results】1.Compared with normal control group,plasma levels of TAT,vWF and DD were elevated before treatment in acute leukemia patients(P＜0.01),except for the upgrade of TAT and vWF,there were a great deal of elevation of DD in APL patients.2.During the treatment,plasma levels of vWF were much higher in patients than that before treatment(P＜0.01). 3.After complete remission(CR),TAT remained high in Acute Leukemia (AL).4.Compared with other AL patients,plasma levels of TAT,VWF and DD increased in APL patients before treatment.After treating the APL patients by ATRA for 7 days,we find TAT,vWF and DD content were lower than before, the difference is significant(P＜0.01).The plasma levels of DD decreased into normal levels after treatment for 21 days,but the levels of TAT was not recovery.【Conclusions】Activation of the injury of vascular endothelium,coagulation and fibrinolysis existed in patients and were improved with amelioration of the disease.Fibrinolysis was the main reason of the serious hemorrhage patients, TAT and DD may be helpful in the proper management of patients during the use of antithrombin and/or antifibrinolytic agents.The three index were much higher much higher in APL that in other in other AL,which showed that there were relationship between disorder of coagulation and high level of TAT,vWF and DD.ATRA could take some role in correcting coagulant and fibrinolytic disorders,and then lessen the haemostatic disturbance in APL patients.In addition,the prevention of hypercoagulability after treatment should be kept in mind.Therefore,Monitoring in different prase the content of plasma TAT,vWF and DD in acute leukemia provided the the evidence in theory for early diagnosis prevention and cure of acute leukemia in clinic.