| Osjectives: We intended to describe the optimal time of chaotic electrical stimulation on subthalamic nucleus(STN)and evaluated the efficiency of chaotic electrical stimulation for controlling intractable epilepsy, then discussed on the potential mechanism, which provided evidence for treating pharmacological intractable epilepsy patients in such a way stereotatic functional neurosurgery.Methods: The clean SD rats were randomly divided into six groups, the experimental epilepsy model of rat was iuduced by pentylenetetrazole (PTZ), which received chaotic electrical stimulation of the STN at different time, at the same time, we observed and recorded the latence of seizure and the EEG, the mossy fiber sprouting of hippocampus was evaluated by Golijeh's score.Result: Compared to the control group, STN chaotic electrical stimulation significantly prolonged the latency of of seizure of stage I and stageâ…£,shorten the last time of seizure ,supressed epileptiform discharge and mossy fiber sprouting of hippocampus.The difference of the anticonvulsive effect between the synchronize stimulation group and pre-stimulation group was significant. The same conclusion was yielded between the synchronize stimulation group and post-stimulation group acording to statistics methods. However, statistical analysis showed that there was no difference between pre-stimulation group and pre-stimulation group in the anticonvulsive effect.Conclusion: Chaotic electrical stimulation of STN can significantly prolonged the latency of seizure, shorten the last time of seizure and supressed epileptiform discharge. The optimal time of chaotic electrical stimulation of STN was preictal seizure.The effect may be associated with chaotic electrical stimulation keep high-dimensional chaos of EEG activity and restraining mossy fiber sprouting of hippocampus. |
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