The Changes And Significance Of Plasma ET-1,ANP And TXB2 In Patients With Type 2 Diabetes Mellitus

Objective This study was designed to investigate the changes of plas-ma ET-1, ANP, TXB2 and their roles in the pathogenesis of diabetic macroan-giopathy, and to provide evidence for early diagnosis and treatment of diabeticmacroangiopathy.Methods Plasma levels of ET-1, ANP and TXB2 were measured withRIA in 60 cases of type 2 diabetic patients (43 patients with and 17 without overt diabetic macroangiopathy) and 31 cases of healthy subjects.Results 1. Plasma levels of ET-1 in type 2 diabetic patients with and without macroangiopathy were significantly higher (P<0.01) than those in hea-lthy controls (94.75±33.02 pg/ml, 77.51±11.22 pg/ml versus 47.20±12.16 pg/ml,respectively); Plasma levels of ET-1 in type 2 diabetic patients with macroan-giopathy were significantly higher (P<0.05) than those without macroangiopat-hy (94.75±33.02 pg/ml versus 77.51±11.22 pg/ml, respectively).2. Plasma levels of ANP in type 2 diabetic patients with and without macroangiopathy were significantly higher (P<0.01) than those in hea-lthy controls (411.51±46.68pg/ml, 389.05±13.34pg/ml versus 163.88±17.87pg/ml, respectively); Plasma levels of ANP in type 2 diabetic patients with macroan-giopathy were significantly higher (P<0.05) than those without macroangiopathy (411.51±46.68 pg/ml versus 389.05±13.34 pg/ml, respectively).3. Plasma levels of TXB2 in type 2 diabetic patients with andwithout macroangiopathy were significantly higher (P<0.01) than those in healt-hy controls (430.75±57.39 pg/ml, 237.25±92.56 pg/ml versus 80.79±33.80 pg/ml,respectively). Plasma levels of TXB2 in type 2 diabetic patients with macroan-giopathy were significantly higher (P<0.01) than those without macroangiopathy(430.75±57.39 pg/ml versus 237.25±92.56 pg/ml, respectively). 4. Plasma levels of ET-1 had positive correlation with plasma le-vels of ANP and TXB2 (r =0.798, 0.601, P<0.01, respectively). Plasma levelsof ANP had positive correlation with plasma levels of TXB2(r=0.823, p<0.01).HbA1c, FPG and the history of diabetes and hypertension all had positive corr-elation with plasma levels of ET-1, ANP and TXB2, and HDL-C negative cor-relation; TG had positive correlation with plasma levels of ET-1 as well. And BMI, SBP, DBP, TC, LDL-C, APOA1, APOB, APOA1/APOB and age didn't correlate with plasma levels of ET-1, ANP and TXB2 in type 2 diabetic patie-nts.Conclusions 1. Plasma levels of ET-1, ANP and TXB2 in type 2 diabet-ic patients were higher than those in healthy controls; plasma levels of ET-1, ANP and TXB2 in type 2 diabetic patients with macroangiopathy were higher than those without macroangiopathy;So we presume that ET-1, ANP and TXA2may have play an important role in the pathogenesis of diabetic macroangiopa-thy. Determination the levels of ET-1, ANP and TXB2 in type 2 diabetic pati-ents may be useful for detecting diabetic macroangiopathy early.2. Plasma levels of ET-1 had positive correlation with plasma lev-els of ANP and TXB2. Plasma levels of ANP had positive correlation with pl-asma levels of TXB2. So we suppose that ET-1, ANP and TXA2 may cooper-ate with each other during the occurrence of diabetic macroangiopathy. More samples are needed for further study.3. HbA1c, FPG and the history of diabetes and hypertension all c-orrelated positively with plasma levels of ET-1, ANP and TXB2, and HDL-C correlated negatively; TG correlated positively with plasma levels of ET-1 as well. So we believe that long-standing hyperglycemia, hypertension and lipid metabolic disorder promote the occurrence of diabetic macroangiopathy.