Effects Of Acanthopanax Senticosus Extracts On Antioxidative Function And Intestinal Development In Piglets

Studies in recent years found that the application of antibiotics in feed additives asgrowth promoters might induce bacterial resistance. Some countries have preventedantibiotics from using in feedstuff. Development and exploitation of new types of safe feedadditives to replace antibiotics were necessary. We chose Chinese herbal medicineAcanthopanax senticosus as feed additive in our research.In this paper, the effects of Acanthopanax senticosus extracts on antioxidative functionand intestinal development in piglets were studied. A total of 192 healthy Landrace×LargeYorkshire two-line crossbred piglets of seven-day old were randomly divided into eightgroups, each included three replicates of eight pigs. With the control of 0mg/kg to based diet,treatment groups were supplemented with 50, 100, 200, 1000mg/kg Acanthopanax senticosusethanolic extracts, 200mg/kg Acanthopanax senticosus aqueous extract, 10g/kg Acanthopanaxsenticosus powder, and 200mg/kg aureomycin, respectively. After seven and fourteen daysfeeding, three piglets were selected from each group randomly and Slaughtered to collectserum, liver, and intestine samples.The study on the antioxidative function indicated that the activities of glutathioneperoxidase (GSH-PX) in serum and superoxide dismutase (SOD) In liver of the pigletsincreased in the 50mg/kg Acanthopanax senticosus ethanolic extract treatment group incontrast to the control, and the activities of glutathione peroxidase (GSH-PX) in serum andcatalase (CAT) in liver of the piglets in this group increased in contrast to the the 200mg/kgaureomycin. The content of maleic dialdehyde (MDA) decreased in 200mg/kg Acanthopanaxsenticosus aqueous extract group compared with the control.For the intestinal development, there was increase at the activities of disaccharidase andtrypsin in the treatment group supplemented with 50mg/kg Acanthopanax senticosusethanolic extract compared with the control. And in contrast to the 200mg/kg aureomycingroup, the activities of disaccharidase, lipase and trypsin increased in this group. For thetreatment groups of 50mg/kg Acanthopanax senticosus ethanolic extract and 200mg/kgAcanthopanax senticosus aqueous extract, both of jejunal and ileal villus of piglets werehigher than the control, and the incidences of diarrhea and mortality in piglets were reduced.This study indicated that 50mg/kg Acanthopanax senticosus ethanolic extract and200mg/kg Acanthopanax senticosus aqueous extract were the optimal dose.