The Change And Clinical Significance Of T Lymphocyte Subsets In Patients With Coronary Atherosclerotic Heart Disease At Pretherapy And Post-therapy

Objective: To determine the level of T lymphocyte subsets in peripheral blood of thepatients with coronary atherosclerotic heart disease at pretherapy and post-therapy,and further discuss the pathogenesis of coronary atherosclerotic heart disease and itsclinical significance from a view of immunology.Methods: based on the diagnose criteria of coronary atherosclerotic heart disease, thepatients with acute myocardial infarction, unstable angina pectoris and stable anginapectoris were selected respectively, 20 patients in each group. The levels of CD3,CD4,CD8 and the ratio of CD4/CD8 of T lymphocyte subsets in peripheral blood ofall patients at admission were determined by using an indirect immuno-fluorescenceassay and compared with those of normal control respectively. In addition, the levelsof CD3,CD4,CD8 and the ratio of CD4/CD8 of T lymphocyte subsets in peripheralblood were determined for patients with acute myocardial infarction at 7 days and 14days post-therapy and patients with unstable angina pectoris at 7 days post-therapyand compared with those of patients at pretherapy respectively.Results: Compared with normal control, unstable angina pectoris and stable anginapectoris, patients with acute myocardial infarction had obviously lower CD3, CD8levels of T lymphocyte subsets (all P＜0.01), and a relatively higher ratio ofCD4/CD8 (P＜0.01) at admission. Their levels of CD3 and CD8 obviously increased(all P＜0.01) and ratio of CD4/CD8 decreased (P＜0.01) at 7 and 14 dayspost-therapy related to admission. The levels of CD3,CD4 and the ratio of CD4/CD8of T lymphocyte subsets in patients with unstable angina pectoris at admission had noobvious differences with those in normal control (all P＞0.05), while the level of D8 had a remarkable difference with that of normal control (P＜0.01). For patients withunstable angina pectoris, CD3,CD4,CD8 levels and CD4/CD8 ratio of T lymphocytesubsets had no obvious differences between at 7 days post-therapy and pretherapy (allP＞0.05). The level of T lymphocyte subsets in patients with stable angina pectoris atadmission had no obviously difference with normal control (P＞0.05)Conclusions: immunoreaction participates in occurrence and development ofcoronary atherosclerotic heart disease, thus the pathogenesis of coronaryatherosclerotic heart disease is related to function and quantity of immunocompetentcells. The level of T lymphocyte subsets is obviously reduced for patients with acutemyocardial infarction at admission, indicating that the immunity function of this kindof patients has a remarkable disturbance, which is presented by the weakening oforganisms immunorepression. For patients with acute myocardial infarction, the levelof T lymphocyte subsets markedly increase after salvage, reflecting that theweakening of immunorepression is modified and immune disbalance is recovered. Inaddition, for patients with stable angina pectoris at pretherapy and unstable anginapectoris at pretherapy and post-therapy, the level of T lymphocyte subsets has noobvious differences, indicating that immunobalance of both kinds of patients is stillremained even at seizure of disease.