The Effects Of Acute Cerebral Thromboembolism In Rats On Phospholipids And The Influence Of Buchang Naoxintong Capsule On It

Aim;To investigate the changes of the plasma Phospholipids concentration and the effect of Buchang Naoxintong on it after Acute Cerebral Thromboembolism in rats.Methods;twenty-four wistar rats were randomly divided into five groups(n=6 each):normal control,sham-operation,ischema,and Buchang naoxintong pretreatment.An embolus was placed at the origin of the middle cerebral artery(MCA)by injection of autologous single blood clot via an intraluminal catheter placed in the intracranial segment of internal carotid artery.The concentrations of LPA and PA were quantified by ultraviolet spectrophotometry.Results A total of 24 rats were involved in the result analysis:①The concentrations of plasma LPA(12.47±1.65)umol/L and PA(10.51±0.98)umol/L in the ischemia group was higher compared with the normal control group(2.41±0.17)umol/L(p＜0.05 )and(3.11±0.60)umol/L respectively.②The concentrations of plasma LPA and PA decreased significantly in Buchang naoxintong pretreatment group.Conclusions:The concentrations of plasma LPA and PA increases differently after cerebral thromboembolism.Pretreatment with naoxintong can decrease the concentration of plasma LPA in rats,and inhibit the increasing of concentration of plasma PA.Buchuang Naoxintong capsule can inhibit the formation of the cerebral infarction from different ways,different links and different targets,the leech component is the direct Thrombase inhibitor,danshen root component had the analogical biological effect of ADP-receptor antagonist,libanotus and Carthamus tinctorius have the effect of platelet aggregation inhibition and blood Viscosity depression.Scorpion and Ailolobophora caliginosa trapezoides had the effect of anticoagulation.etc So,Buchuang Naoxintong capsule can improve the neural function.Reduce brain edema,and protect the neurons in rats with cerebral infarction.The improvement of cerebral infarction has a positive correlation with the use of naoxintong.It can affect the blood and the blood vessel itself and adjust the the concentrations of plasma LPA and PA.