MCP-1 Level In The Serum Samples Of Patients With ACS And The Changes Of CCR2 Expression On The Monocytes

Background: Recently more and more attention has been paid to the relationship between inflammatory reaction and cardiovascular disease. Monocyte chemoattractant protein-1 (MCP-1), an important chemokine in the process of inflammatory reaction, activates and induces adhesion of monocyte cells to endothelial cells. However,CC chemokine receptor 2(CCR2) is the main receptor of MCP-1, through which MCP-1 realize most of its function. The objective of the present study was to determine MCP-1 expression in patient with acute coronary syndrome(ACS) and the CCR2 expression on monocytes stem from those patients. Furthermore we explore the function of CCR2 in the pathogenesis of ACS.Methods: 30 patients with ACS and 30 healthy controls were enrolled in the present study. In order to assess the expression of MCP-1, ELASA is used on the serum stem from those patients. 10 patients and 10 controls were selected randomly from the 2 groups respectively. CCR2 expression on monocytes is assessed using flow cytometry.Results: (1) MCP-1 concentration of the serum samples were fluctuated around(59.9±26.1pg/m)in healthy controls and (75.5±28.2pg/ml) in ACS patients. Compared with controls, MCP-1 levels of the patients with ACS were significantly elevated (P=0.027) (2) CCR2% on monocytes is fluctuated around (53.5±8.2) in healthy controls and ( 84.9±10.7) in ACS patients. CCR2 expression on the monocytes belonging to ACS patients was elevated(p=0.000).Conclusion: (1) Elevation of MCP-1 levels of the patients with ACS shows that MCP-1 functions a lot in the process of ACS.2) Elevation of CCR2 expression on the monocytes belonging to ACS patients shows that monocytes of ACS patients harbors more sensitivity and are more stimulating in the process of ACS.