The Protective Effect Of Anisodamine On Lung Injury During Cardiopulmonary Bypass

Objective: The purpose of this study was to investigate the effect of anisodamine on lung injury during cardiopulmonary bypass.Methods: Twenty four patients scheduled for elective valve replacement under cardiopulmonary bypass, which had no significant difference existed between two groups in ASA grade, age and body height,no signs of liver function failure and renal failure; left ventricle ejection fraction exceed 40%; blood routine examination is normal probably; no history of chronic bronchitis, bronchial asthma, glaucoma and prostatauxe; no pulmonary infection or receiving hormone in these days, were randomly divided into two groups of 12 patients each. In the experimental group, the patients received anisodamine 0．8mg/kg by adding into the primary solution at the beginning of by-pass,with control group received normal saline instead of anisodamine. Blood samples were taken from radial artery for determination of IL-6 and TNF-αconcentrations and blood gas analysis before operation(T₁) , 30min after initiation of cpb(T₂) , 1h(T₃) , 4h(T₄) and 24h(T₅) after cpb. Respiratory index was calculated at T₁, T₃, T₄．Results: The age, sex ratio, body weight, time of cpb and time of blocking aorta had no significant difference in both groups(P>0．05) . The plasma levels of TNF-α,IL-6 and respiratory index had no significant difference in both groups at T₁(P>0．05) . In control group the plasma levels of TNF-α,IL-6 were significantly higher than the baseline values during and after cpb(P<0．05) .TNF-α, IL-6 concentrations and respiratory index were significantly higher in control group than in experimental group after cpb(P<0．05) .Respiratory index was positively correlated with plasma concentration of TNF-αand IL-6．The "r" were 0．70 and 0．67(P<0．01) .Conclusion: This results show that anisodamine can effectively suppress the production of the cytokine during cpb, so reduce the systemic inflammatory response and protect respiratory function.