Association Studies Of The Relationship Between GSTM1, GSTT1 Gene Polymorphism And Susceptibility To Endometriosis In Women Of Han Nationality In Hunan Provice

Objective: To evaluate the possible association of the glutathione S-transfera-se (GST) M1, T1 null genotype with the susceptibility to endometriosis in women of Han nationality in Hunan province.Methods: Polymerase chain reaction (PCR)was used to identify the GSTM1, T1 genotypes in 74 patients with endometriosis and 65 controls (surgical patients for gynecological problems other than endometriosis).Results: The frequencies of the GSTM1 null genotypes in patients with endometriosis and controls were 64.86% and 46.15%, showing no significant difference between the endometrisis group and controls group (X~2=4.92, P=0.027＜0.05); The frequencies of the GSTT1 null genotypes in patients with endometriosis and controls were 62.16% and 49.23%, showing no significant difference between the endometriosis group and controls group (X~2=2.35, P=0.13＞0.05); The frequencies of combining GSTM1 null genotype and GSTT1 null genotype in patients with endometriosis and controls were 36.49% and 20.00%, showing no significant difference between the endometriosia group and controls group (X~2=4.59, P=0.032＜0.05).Conclusion: The significant associations were found between GSTM1 null genotype and GSTM1 null genotype in combination with GSTT1 null genotype and the susceptibility of endometriosis. There was no significant association between GSTT1 null genotype and endometriosis in women of Han nationality who are native redidents in Hunan provice.