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Survival Analyses Of Five Cancers Among Urban Residents In Liaoning Province

Posted on:2008-04-23Degree:MasterType:Thesis
Country:ChinaCandidate:L Y YuFull Text:PDF
GTID:2144360215981311Subject:Epidemiology and Health Statistics
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Survival Analyses of Five Cancers among Urban Residents in Liaoning ProvinceObjectiveCalculate OSR, RSR and T50 of breast, colorectal, stomach, lung and liver cancer of residents in Liaoning urban, and analyses the relation of the stage of diagnosis, therapy and survival.MethodRandomization was used to identify 2872 subjects of breast, colorectal, stomach, lung and liver cancer of Shenyang, Anshan, Benxi 2000 cancer registry. Survey on survival retrospectively used questionnaire of diagnosis and treat, survival outcome. Collection clinical information through extracting medical record and home interview and verify survival outcome through Liaoning death database and police information and home interview. Calculate 1-5 years OSR, T50 of the five cancers and five year OSR, T50 by age, sex, stage, therapy, site of the five cancers, and test survival curve by Wilcoxon(Gehan) test used SPSS 11.5 Life table method. Calculate ESR by 2002 life table of residents in Liaoning urban. Se(t)=∑nxSex(t)/∑nx, nx was number of subjects at age of X, Sex(t) was survival probability on the time of t from age of X. Estimate RSR by the formulation: RSR=(OSR/ESR)×100%.Result2295 subjects was took into analyses. Passive follow-up rate was 92%. T50(month) of breast, colorectal, stomach, lung and liver cancer was 72.00+, 54.55, 18.00, 11.16, 7.66 and the five year OSR was 74.31%, 45.63%, 25.88%, 14.31%, 9.43%and five year RSR was 78.74%, 57.15%, 33.09%, 18.68%, 11.81%. The five year OSR of liver cancer was significantly greater for female than male (P=0.0128) and the colorectal (P=0.6734), stomach (P=0.1041), lung (P=0.0994) cancer has not significant sex difference. The survival decreased with increasing of age at diagnosis of breast (P=0.0013), colorectal (P=0.0001), stomach (P=0.0001), lung (P=0.0031) and liver cancer (P=0.0227). The survival decreased when cancer stage evolved of breast (P=0.0000), colorectal (P=0.0000), stomach (P=0.0000), lung (P=0.0000) and liver cancer (P=0.0427). The difference for 5 year OSR of breast, colorectal, stomach, lung and liver cancer between distant and localized was 55.55%, 38.99%, 30.27%, 18.66%, 10.7%and for the T50(month)was 48+, 60+, 30, 14.4, 1.57. 5 year OSR of localized colorectal (χ2=11.138, P<0.05), stomach (χ2=13.310, P<0.05), lung (χ2=5.487, P<0.05) was significantly greater for surgery group than non surgery group. The difference for 5 year OSR of localized colorectal, stomach, lung cancer between surgery and non surgery was 30.28%, 37.12%, 16.50%and for the T50(month) was 49.20+, 50.67, 31.27. 5 year OSR of localized liver, distant colorectal, regional and distant stomach, lung was not significantly greater for surgery group than non surgery group.Conclusion1,T50(month) of breast, colorectal, stomach, lung and liver cancer was 72.00+, 54.55, 18.00, 11.16, 7.66 and the five year OSR was 74.31%, 45.63%, 25.88%, 14.31%, 9.43%and five year RSR was 78.74%, 57.15%, 33.09%, 18.68%, 11.81%.2,The survival decreased when cancer stage evolved.3,5 year OSR of localized colorectal, stomach, lung was significantly greater for surgery group than non surgery group. 5 year OSR of localized liver, distant colorectal, regional and distant stomach, lung was not significantly greater for surgery group than non surgery group.4,The key of improvement on survival of residents in Liaoning urban was to improve the diagnosis of localized breast, colorectal, stomach, lung and to surgery on the patients. We should strength surgery on localized lung cancer.5,There was a certain gap between Liaoning and developed country in the early diagnosis of liver cancer and therapy of the cancers such as breast and colorectal which already has efficient therapy.
Keywords/Search Tags:OSR, RSR, T50, Stage, Surgery
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