Patients Infarct Correlation Of Serum High-sensitive C-reactive Protein Level And Carotid Atherosclerosis In Acute Cerebral

PrefaceInvestigation shows that atherosclerosis is the patho-base of cerebral arterial thrombosis and chronic inflammation process plays a key-role in the formation and development of Atherosclerosis. High sensitive c-reactive protein, (hs-CRP) is a sensitive index in organism Inflammatory reaction. At present hs-CRP is also a risk factor in the mortality and death of cordis-cerebrovascular disease. The purpose of my experiment is to study the relationship Objectivly between serum high—sensitivity C-reactive protein (hs-CRP) level and carotid atherosclerosis in acute cerebral infarct patients. To reveal whether or not hs-CRP Level is associated with carotid intimal-medial thickness(IMT) and instability of plaque with acute cerebral infarct patients can hint hs-CRP is a risk factor in acute cerebral infarct patients with atherosclerosis which confirm inflammatory reaction maybe participate the form of atherosclerosis inacute cerebral infarct patients.Materials and MethodsChoose one hundred and two patients with acute cerebral infarct which were in nerves medical ward of ShenZhou hospital affiliated to ShenYang medical college for cerbral infarction group concluding fifty-five men and forty-seven women age for fifty-five to eighty-six years old. Bring into Standard: all fit the diagnose of every cerebrovascular disease which is instituted in the four reach cerebrovascular disease academic meeting; all with final diagnosis course of disease; all with acute stage. Remove Standard: with liver kidney or heart nonfunction; with patient history of phymatosis; with systemic infection; with operation external injury and rheumatic heart disease. Choose ninety-six healthy person for control group concluding fifty-one men and forty-five women age for forty-eight to seventy-eight years old. The two groups have non difference in age and sex which can be compared.The serum concentrations of high sensitive C reactive protein (hs-CRP)were measured in one hundred and two patients with acute cerebral infarct and in ninty-six healthy people. A Color Doppler Ultrasound system was used to investigate the intimal-medial thickness(IMT)of common carotid artery(CCA)and the plaque of carotid artery.Results①Contradisting Serum high—sensitivity C-reactive protein level with non carotid atherosclerosis in patients with acute cerebral infarct and in the control group, the former is higher than the latter (P＜0.05), the contradisting Serum high—sensitivity C-reactive protein level with carotid atherosclerosis in patients with acute cerebral infarct and in the control group, both have non-difference. (P＞0.05).②The serum concentrations of hs-CRP in the group with IMT increasing were signicantly higher than that in the carotid artery normal group(P＜0.01).③The serum concentrations of hs-CRP in the carotid artery plaque group were signicantly higher than that in the non-carotid artery plaque group(P＜0.01). These findings were also present in the group with IMT increasing(P＜0.01).④The serum concentrations of hs-CRP in the carotid artery non-stabale plaque group were higher than that in the-carotid artery stabale plaque group(P＜0. 05)DiscussionRecently investigation shows that atherosclerosis is an important risk factor in cerebrovascular disease.The ultrasonic sign of atherosclerosis is intimal thickening plaque-form and lumina narrow. Intimal thickening is the earlier show of atherosclerosis, plaque-form is the typical example of atherosclerosis and lumina narrow is the advanced stage show.Investigation verifies that chronic inflammation of vessel wall is the important patho-process during the atherosclerosis disease. Hs-CRP is one of the tumor marker in atherosclerosis, inflammation and fiber hyperplasy reaction. There is a positive relationship between the density of hs-CRP with atherosclerosi patients and degree of vascular lesion. So we can reflect to some extent the degree of vascular lesion and the progress of atherosclerosis.Our study hints that Contradisting Serum Hs-CRP level with non carotid atherosclerosis in patients with acute cerebral infarct and in the control group, the former is higher than the latter (P＜0.05), the contradisting Serum Hs-CRP level with carotid atherosclerosis in patients with acute cerebral infarct and in the control group, both have non-difference. (P＞0.05).We consider that when there is no carotid atherosclerosis the excitable factor of cerebrovascular disease is the main cause in the heighten of Hs-CRP while atherosclerosis is the main effect to the heighten of Hs-CRP when there hane carotid atherosclerosis.Our study find that Serum Hs-CRP level with carotid atherosclerosis in patients with acute cerebral infarct is higher than the control group with carotid non atherosclerosis,and Serum Hs-CRP level is significant higher with the aggravation in degree of atherosclerosis Which hints that Serum Hs-CRP level is associated with carotid atherosclerosis in patients with acute cerebral infarct.Our study find that the serum concentrations of Hs-CRP in the carotid artery nonstabale plaque group were higher than that in the-carotid artery stabale plaque group which verified that there is relevance in inflammation and the instability of atherosclerosis plaque. The existence of unstable plaques inflammation may be lead to secondum plaque morphology and component proportional change which promote the unstable plaques play an important role in the break of atherosclerosis plaque. The break of atherosclerosis plaque which cause to bleed thrombose and amtio can cause to happen cerebral infarction. In a word detecting the level of Hs-CRP has a characteristic of hadro-operating and simple performing. We can prevent the atherosclerosis progress and recidivation of cerebral accidence by clinical monitoring and necessary intervention therapy to the patients with higher level of Hs-CRP.ConclusionSerum high—sensitivity C-reactive protein level is associated with carotid atherosclerosis in patients with acute cerebral infarct.Inflammatory response might play an important role in the pathogenesis of carotid atherosclerosis with acute cerebral infarct. There is a positive relationship between Inflammation and unstable plaques of carotid atherosclerosis in patients with acute cerebral infarct.