Relationship Between XRCC1 Polymorphisms, Living Habits And Susceptibility Of Prostate Cancer In Population Of Han Nationality In Southern China

ObjectiveTo investigate the association among XRCC1 polymorphisms, living habits and the risk of PCa in population of Han nationality in Southern China.MethodsIn a case-control study of 207 patients with prostate cancer and 235 cancer-free controls frequency-matched by age. We genotyped three XRCC1 polymorphisms (codons 194, 280, and 399) using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.ResultsAmong the three polymorphisms, we found that the XRCC1 Arg399Gln variant allele was associated with increased prostate cancer risk (adjusted OR=1.67, 95% CI: 1.11-2.51), but the XRCC1 Arg194Trp variant allele had a 38% reduction in risk of PCa (adjusted OR=0.62, 95%CI: 0.41-0.93). However, there was no significantly risk of PCa associated with Arg280His polymorphism. When we evaluated the three polymorphisms together, we found that the individuals with 194Arg/Arg wild-type genotype, Arg280His and Arg399Gln variant genotypes had a significantly higher risk of PCa (adjusted OR=4.31; 95%CI: 1.24-14.99) than those with three wild-type genotypes. In addition, we found the Arg399Gln variant genotypes had a significantly risk of PCa among heavy smokers (adjusted OR=2.04; 95%CI: 1.03-4.05).ConclusionsThese results suggest that polymorphisms of XRCC1 appear to influence the susceptibility to PCa. There were many interactions among predisposing genotypes and have synergistic effect with smoking.