| Objective: To study the protective effects of propofol in different doses on intestine in rabbits with endotoxemia.Methods: Endotoxemia was replicated by continuous infusion of E-coli lipopolysacchaide (LPS) in rabbits. Forty New Zealand rabbits, weighting 2.50～2.70 kg, male or female, were randomly divided into 5 groups: A, normal controls (n=8); B, LPS group (n=8), receiving intravenous endotoxin (LPS 600μg/kg); C, low-dose group (n=8), D, medium-dose group (n=8), E, high-dose group (n=8, receiving propofol 5 mg·kg-1·h-1, 10 mg·kg-1·h-1 and 15 mg·kg-1·h-1 respectively and LPS 600μg/kg). The specimens were collected 4 hours later. We observed the following changes: plasma diamine oxidase (DAO) activity, intestine tissue myeloperoxidase (MPO) activity, intestine tissue superoxide dismutase (SOD) activity, intestine tissue malonaldehyde (MDA) content. We also monitored the pathological changes with HE stainin.Results: Plasma DAO activity, intestine tissue MPO activity and intestine tissue MDA content in group C, D and E decreased significantly compared with those of group B (P＜0.05). Intestine tissue SOD activity in group C, D and E increased markedly compared with group B (P＜0.05). There was less degree of injury of intestinal mucous membrane in group C,D and E compared with group B in pathological examinations.Conclusion: Propofol has a protective effect on intestine in rabbits with endotoxemia. Different dose of propofol has different effect, which is not positively correlated with the dosage.
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