Study On Expression Of Inhibitors Of DNA Binding-1(Id-1) Protein In Human Colon Cancer And Its Clinicopathological Significance

Objective To detect the expression of inhibitors of DNA binding-1 (Id-1) protein in human colon cancer and investigate the relationship between the expression of Id—1 protein and histological grade, invasion, lymph node metastasis, TNM stage of colon cancer.Methods Immunohistochemistry was used to detect the expression of Id-1 protein in 52 cases of human colon carcinomas, 15 cases of the adjacent normal colon tissues, 16 cases of dysplasia(DYS), and 17 cases of adenoma.Results The Id-1 protein expression was almost not observed in normal colon tissues, and the rate of Id-1 positive expression in adenoma,DYS and colon carcinomas were 29.4%,43.75%,73.1%, respectively, which was increased with the lesion progression(P<0.05). Id—1 expression in colon carcinomas with low histological grade was higher than that in carcinomas with higher histological(P<0.05). Positive rate of Id—11 expression in 35 cases with lymph node metastasis was 82.9%(29/35), which was higher than those without lymph node metastasis(P<0.05) .With depth of invasion increasing, stage of TNM upgrading, the positive expression of Id—1 protein in colon carcinomas significantly ascended (P<0.05) .The rate of Id-1 positive expression was related to invasion, differentiation, metastasis and TNM stage in colon cancer,and no related to age.Conclusions Id-1 might play an important role in the development of invasion and metastasis of colon cancer.