The Histologic Changes And Expression Of Platelet-derived Growth Factor In Human Benign Prostatic Hyperplasia With Chronic Inflammation

ObjectiveTo study the incidence of chronic prostatitis in the patients with benign prostatichyperplasia(BPH) and describe histologic characteristics of patients with BPH. Toinvestigate age on set and prostate volume of the patients in both simple BPH groupand BPH with chronic prostatitis group. To studying the expression of platelet-derivedgrowth factor(PDGF) in human prostate tissue and to research the role of PDGF inBPH formation and effect of chronic inflammation on the expression of PDGF.Methods1. The study included 64 patients diagnosed BPH by pathologic examination duringMarch to December 2006, HE stain method was used to investigate the incidenceof chronic inflammation and histologic changes in prostatic tissue.2. The 64 patients were divided into two groups by histologic diagnostic criteria ofchronic prostatitis: simple BPH group and BPH with chronic inflammation group.Age on set and prostate volume were recorded and compared in both two groups.3. Expression of PDGF was assayed in both two groups using SPimmunohistochemical technique.Results1. Inflammation was idcntified in all 64 patients, periglandular inflammation wereseen in 54 patients(84.3%), glandular inflammation were seen in 40patients(62.5%) and stromal inflammation were found in 36 patients(56.23%).Both periglandular inflammation and glandular inflammation were found in 30patients. 30 patients (46.9%) were diagnosed BPH with asymptomaticinflammatory prostatitis.2. Age on set(P=0.036＜0.05) and prostate volume(P=0.023＜0.05) both hadsignificant statistical difference between simple BPH group and BPH with chronicprostatitis group.3. The expression of PDGF was found in glandular epithelium cell, stroma fibroblast and smooth muscle cell. The prostate tissue of BPH with chronic prostatitis group hadincreased expression of PDGF(96.7%), with average gray scale 81.69±4.78; whilesimple BPH group had lower expression of PDGF, with average gray scale108.43±14.41. There was significant statistical difference between two groups(P=0.000).Conclusion1. Inflammation is an extremely common histologic characteristics in prostate tissueof BPH. Foci of inflammation were categorized as periglandular, glandular andstromal. Samples with the three types can be diagnosed BPH with asymptomaticinflammatory prostatitis.2. 46.9% of the 64 BPH patients were asymptomatic inflammatory prostatitis.3. The average prostate volume of BPH with chronic prostatitis group significantlybigger than that of simple BPH group. And this result suggested inflammationplay a part in BPH.4. The positive PDGF expression cell population and the PDGF content of prostatesample in BPH with chronic prostatitis group were much more than that of simpleBPH group. And this result suggested chronic prostatitis play a part in BPH byreleaseing PDGF.