To Examine The Relationship Between The Prostate Specific Antigen And The Female Urethral Syndrome.

Objective:1. In order to explore there is PSA in the women's serum or not.2. Observation on PSA during the fertile age and after menopause.3. To find out the relationship between serum PSA and female urethral syndrome.4. Measuring the serum PSA to investigate that the existence of female prostate or not.5. Search for the usage of the serum PSA besides the prostate diseases.Methods:1. Selected 21 patients that were identified diagnosis of the female urethral syndrome,measured the T-PSA (total prostate specific antigen) values and F-PSA (free prostatespecific antigen) values; selected 20 healthy volunteers took a morning fastingvenipuncture blood sample, measured the T-PSA values and F-PSA values, compared thedifference of the PSA measures between the patient group and the healthy group, the datawere performed with statistical analyses, to study that the difference of PSA values isassociated with female urethral syndrome or not.2. The trained observers were grouped into fertile age group and after menopause group,measured their T-PSA values and F-PSA values, statistical calculation were performed tothe data, to analyze the difference of the serum PSA values between the groups.Results:1. 13 patients (61.90%) were found in the patient group that the measured serum T-PSAvalues were positive; and in the control subjects 5 samples (20.00%) had measured serumT-PSA values, using the X~2 test, X~2= 5.665, the probability (p) value = 0.017, and p valuebelow 0.05 were considered statistically significant.2. 7 patients (33.33%) had measured serum F-PSA were positive, no serum F-PSA was seenin the healthy group. 3. The particular connection between age and serum T-PSA value was assessed by using thelinear correlation analysis, the correlation coefficient (r) is 0.256, the p-value is 0.106,p＞0.05, no linear correlation relationship.4. 13 samples (59.10 %) were found in the women after menopause that had measured theserum T-PSA values, and in 5 women (26.32%) of fertile age, by X~2 test, X~2= 4.47, p=0.035, p＜0.05, were considered significant.Conclusions:1. PSA (prostate specific antigen) has been detected in female serum.2. The level of serum PSA in women after menopause increased, it is speculation that thedecreasing of estrogen's level, the increasing of androgen level relatively.3. The level of serum PSA was higher in after menopause group, hinted that may be existedof a prostate in women.4. The serum T-PSA level was related to the female urethral syndrome, but the serumF-PSA was a non-superior molecule, the result indicates that there was no significationto the F-PSA for the diagnosis of the female urethral syndrome. And the serum T-PSAcan be used as a valuable reference diagnostic indicator for diagnosing of the femaleurethral syndrome that hyperplasia of the para-urethral glands.