Clinical Study On The Effect Of Pingganliqi Method In Treating Premenstrual Syndrome With Invasion Of The Hyperactive Liver-qi

Objective Basing on series of prophase research on premenstrual syndrome with invasion of the hyperactive liver-qi, Random double-blind and double simulation and control method were adopted in this study. The study used tables as Daily Record of Severity of Problems(DRSP) and symptoms score form to evaluate the efficacy of jingqianping granule for treatment of PMS with invasion of the hyperactive liver-qi objectively. Endocrine and neurotransmitters were detected to explore the medicative mechanism of Chinese medicine on PMS.Methods All cases were from the staff of the first Affiliated Hospital, Guangzhou University of TCM. 63 cases were randomly divided into 2 groups, therapeutic group treated with Jingqianping granule and control group treated with placebo both for two menstrual cycles. Reasearcher completed symptoms score form 7 times while patient filled in DRSP and self-estimate table 30 days. All cases' blood samples were collected twice in the third menstrual cycles after treatment. The level of E2, P, PRL, 5-HT, NE, E were examined. Use software SPSS13.0 to analyze all the dates and results.Results①The difference of premenarche to follicular phase and total score of follicular phase of DRSP all decreased significantly after treatment in both groups(P＜0.01). But the control group relieved less than the therapeutic group. The curative effect of two groups did not have significant difference pre-treatment and in treatment. After treatment the therapeutic group was much better than the control group(P＜0.01).②The statistical results of score form was almost the same with DRSP. But the symptoms scores of premenarche did not change with placebo.③The level of E2 rose significantly in the ovulation and luteal phase in therapeutic group, P also rose significantly in luteal phase in therapeutic group. After treatment the level of E2, P in serum of patients had significant difference between two sets during the same period of menstrual cycles(P＜0.01). The PRL of therapeutic group decreased much more than the control group, there was significant difference between two sets(P＜0.01).④Comparing with pretherapy, The level of 5-HT,NE in serum of patients descended significantly in therapeutic group. Therapeutic group regulated 5-HT,NE of PMS patients much better than control group in post-treatment(P＜0.01).Conclusion Jingqianping granule, the deputy of pingganliqi method, has favourable curative effect with premenstrual syndrome invasion of the hyperactive liver-qi patients. Compared with placebo, it can effectively wipe out such premenstrual syndrome as spargosis, stomachache, headache insomnia and dreaminess. The medicative mechanism of Jingqianping granule on PMS maybe that, it can improve the periodic turbulence of sex hormone and the function of corepus luteum. It can reduce PRL in blood-serum as well as the neurotransmitter. The PMS patients are cured by establishing the neuroendocrine balance of the internal environment. The level of E2,P,PRL and neurotransmitter as 5-HT,NE in serum can be the observation index to evaluate the curative effect on PMS with liver-qi. The Chinese version of DRSP and the symptoms score form can be used for clinical diagnosis and curative effect evaluation. Measuring scale would become a new device of differentiation of symptoms and curative effect evaluation generalized in clinical and scientific research.