The Clinical Study Of The Therapy Of Qingganfang For Chronic Hepatitis B

Objective Hepatitis B is a worldwide epidemic caused by viruses. It can cause a wide, formidable and chronic infection. But, there are no specific remedy for this disease. At present, interferon is the preferred remedy, but only 50% patients had responded to the therapy of interferon. At the same time, this therapy can produce a lot of side effect, cost too much and make patients bounce back to bad health if they stop receiving interferon randomly.This study is to investigate the effective and safety of Qingganfang for chronic hepatitis B(CHB).And we will try to find out the therapy of Qingganfang maybe help the patients with chronic hepatitis B get well.And through this study can sieve a effective prescription for the patients of hepatitis B.Method 90 patients were divided randomly to three groups named Qingganfang group, interferon group and compound group, the Qingganfang group was composed of 31 cases, the interferon group 29 cases and the last 30 cases. All of the patients of three groups came from the outpatients of the first subsidiary hospital of Chinese medicine university in Guangzhou from Sep. 2004 to Dec.2006.All of the three groups conform to the diagnosis standard of chronic hepatitis B. All the patients were observed the change both before and after treatment, such as clinical symptoms, physical signs, virul quantitative levels with hepatitis B virus, hepatic function indexes and so on.Result1. The total efficiency of the Qingganfang group was 54.84%. The total efficiency of the interferon group was 75.86%.And the compound group was 86.67% .There was no statistical significance between interferon group and compound group (P＞0.05).But theefficiency was markedly difference from Qingganfang group and another two group.So there is symptomatic curative effect on Qingganfang therapy and interferon therapy.2. After treatment,clinical symptoms and physical signs were improved markedly in the three groups(P＜0.01). There was no statistical significance for the three group in the clinical symptoms such as bumout, hypochondriac pain and loss of appetite (P＞0.05). Improvement of abdominal distension, epigastric fullness, dryness of mouth and bitter taste in Qingganfan group and compound group was superior to those in interferon group (P＜0.05).3. The level of the serums ALT, AST decreased significantly in the three groups(P＜0.01). The level of the serums ALT, AST were no statistical significance between Qingganfang group and interferon group (P＞0.05). But the serum ALT and AST in compound group were lower than those in interferon group and in Qingganfang group significantly. So both the Qingganfang and interferon are effective to lower the serums ALT and AST.If Qingganfang was combined with interferon, the effect of lowering transaminase can be improved.4. All of the patients of three groups were observed both before treatment and 3, 6 months after treatment. The level of the serums ALT, AST decreased gradually during the treatment and the curative effect at a specified future date was better than in the near future.5. All the three groups of the virus quantities decreased significantly(P＜0.01). The virus quantities was no significance between interreron group and compound group after treatment(P＞0.05). But after treatment, the virus quantities of interferon group and compound group were lower than Qingganfang group(P＜0.05). The clearance rate of the three group stenosis was 3.23%,41.37%,46.67%. And the clearance rate of HBeAg of the the three group stenosis was 6.45%,34.48%,40.00%. The clearance rate of HBV-DNA of the compound group was highest in the three group. There was statistical significance between the two groups (P＜0.01). So both of the three therapy can depress the virus replication.And interferon was better than the Qingganfang therapy.Further more interferon combining with Qingganfang can improve inhibit viral duplication.Conclusion Qingganfang and interferon can protect the liver,lower ALT,AST, depress HBV-DNA and improve syndromes of traditional chinese medicine.Qingganfang was better than interferon on improving syndromes of traditional chinese medicine.Qingganfang was the same as interferon at hepatoprotective effect. After treatment, hepatic function indexes ALT, AST of the two groups decreased significantly. The functions of suppressing viral replication, clearing viral of the interferon therapy are better than the Qingganfang therapy.But interferon combining with Qingganfang was the best on all the functions.