The Relationship Between Metabolic Syndrome And Post-stroke Cognitive Impairment

Objective: To explore the relationship between Metabolic syndrome (MetS) and development of cognitive impairment in patients with stroke.Methods: Totally 90 consecutive first-ever stroke patients in the ward of Department of Neurology, the First Affiliated Hospital of Kunming Medical College, were collected during August 2006 to November 2006, including 73 cerebral infarction and 17 cerebral hemorrhage, and were divided into stoke without MetS group (54) and stoke with MetS group (36), according to the diagnostic criteria for MetS defined by Chinese Diabetes Society (CDS) in 2004. All patients were administered to Mini-Mental State Examination(MMSE), Clock Drawing Task(CDT), Verbal Fluency Test(VFT), Trail Making Test-A(TMT-A) in 3 weeks and at 3 months after stroke. The incidence of cognitive impairment and its evolution were assessed in two group subjects.Results: The incidence of cognitive impairment was higher in the stroke patients with MetS than the stroke patients without MetS, 38.9% vs 14.8%(P<. 0. 05) in 3 weeks after stroke and 36. 1% vs 13. 0%(P<0. 05) at 3 months after stroke. The scores of MMSE, delay recall and CDT of the stroke patients with MetS were significantly lower than that of the stroke patients without MetS(P<0. 05) both in 3 weeks and at 3 months after stroke. The stroke patients with MetS had more cognition deterioration than the stroke patients without MetS at 3 months after stroke (P< 0.05).Conclusions: MetS increases the occurrence of post-stroke cognitive impairment.