| Objective: To assess the QOL in liver transplantation recipients and theirfamily members, and then identify related variables influencing their lifequality in order to appraise the long-dated outcome and provide reasonablemethods for improving their QOL.Method: We investigated 72 patients and 46 their family membersconsecutively admitted to the living liver transplantation center, JiangsuProvince hospital in Nanjing, China. Those people completed a questionnairethat included socioeconomic variables, SF-36, SDS, and PSSS scale. Then theresearcher counted their score in SDS, PSSS and SF-36, which include 8 fields:physical function, role-limitation due to physical problems, role-limitation dueto emotional problems, social function, mental health, vitality/fatigue, bodypain and general conception of health. T test, X~2 test, Pearson correlation,Spearman correlation, liner regression and case-control study were used to analyze the data.Results:①Compared to norm population, the male patients groupyounger than 40 had significantly lower score in physical function,role-limitation due to physical problems, social function and body pain (p＜0.05). The female patients group younger than 40 had significantly lower scorein role-limitation due to physical problems and general conception of health (p＜0.05). In male patients group older than 40,the score on 8 fields in SF-36was significantly lower than that in norm population(p＜0.05). In femalepatients group older than 40, the score on role-limitation due to physicalproblems, role-limitation due to emotional problems, social function andgeneral conception of health was significantly lower than that in normpopulation(p＜0.05).②Correlation analysis shows that age of patients wasnegatively correlated with role-limitation due to physical problems and bodypain(p＜0.05); gender of patients was positively correlated with socialfunction(p＜0.05); SDS score was negatively correlated with role-limitationdue to emotional problems, vitality,mental health and general conception ofhealth (p＜0.05); social supports were positively correlated with vitality(p＜0.05); supports from patients' family were positively correlated with socialfunction(p＜0.05); supports from others were positively correlated with mentalhealth(p＜0.05); periods of time after operation were positively correlated with8 fields of SF-36(p＜0.05); educational level of patients was positively correlated with role-limitation due to physical problems(p＜0.05);complications were negatively correlated with role-limitation due to physicalproblems and role-limitation due to emotional problems (p＜0.05); economiclevel of patients was positively correlated with their general conception ofhealth (p＜0.05). Line regression shows that there were many variablesinfluencing QOL in patients with liver transplantation: periods of time afteroperation had effect on 8 fields of SF-36; depression had negative influence onmental health and vitality; educational level had positive effect onrole-limitation due to physical problems; economic level had positive influenceon general conception of health.③The odds ratios of getting lower scorewere as follows: for patients of elder age were 7.53 times as high as those ofyounger age, with depression were 5.77 times as high as without depression,with less family support were 3.47 times as high as with more family support,with complications were 4.26 times as high as without complications.④Compared to norm population, in male family members group younger than 40,the score on role-limitation due to emotional problems was significantly higherthan that in norm populations (P＜0.05); in female family members groupyounger than 40, the score on role-limitation due to emotional problems wassignificantly higher than that in norm population (P＜0.01), the score onrole-limitation due to physical problems and the score on mental health wassignificantly lower than that in norm population (P＜0.05); in male familymembers group older than 40, the score on role-limitation due to physical problems, role-limitation due to emotional problems,social function,mentalhealth and general conception of health was significantly lower than that innorm population (P＜0.05); in female family members group older than 40, thescore on role-limitation due to physical problems, role-limitation due toemotional problems,social function,mental health, vitality and generalconception of health was significantly lower than that in norm population(P＜0.01).⑤Correlation analysis shows that the total score of QOL inpatients was positively correlated with that in their family members(p＜0.01).Conclusion: Patients with liver transplantation and their family membersexperienced unsatisfactory QOL levels that were poorer than those seen in thegeneral population. Through analysis, we discovered factors related to theirQOL level were various. As a result, more attention should be paid to thosepeople and more effective actions should be taken to improve their life quality.
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