Study On The Association Between CYP2E1 Enzymes And Susceptibility Of Alcoholic Liver Disease

Objective To investigate the correlation between the CYP2E1 enzymes and Alcoholic Liver Disease, and investigate the genetic pathogenesis of alcoholic liver disease.Methods Use polymerase chain reaction-restriction fragment length polymorphism(PCR--RFLP)method determined polymorphism of CYP2E1, A case control study of 183 subjects (including40 alcoholic liver disease , 40 alcohol dependent group ,40 other liver disease and 63 controls.Results The frequency of B genotype or C2 allele gene were significantly higher in alcoholic liver disease than in control (P=0.000); The frequency of C2 allele gene were not significantly different between alcoholic liver disease with symptom group and without symptom ; The frequency of C2 allele gene were increased with the degree of liver fibrosis in alcoholic liver disease group (P <0.05).Conclusions C2 gene of CYP2E1 enzymes are related to alcoholic liver disease in Gansu population.