Association Of Interleukin-1 Genetic Polymorphism And Rheumatoid Arthritis In Northwest Chinese Population

Background: Rheumatoid arthritis (RA) is a complex multifactorial disease caused by environmental influences and an unknown number of predisposing genes. With a prevalence of approximately 1% that primarily affects peripheral joints, where synovial inflammation leads to cartilage destruction, bone erosion and ultimately joint deformity and loss of joint function. The present study was undertaken in order to investigate association of Interleukin-1 genetic polymorphisms and rheumatoid arthritis in northwest Chinese population, to provide evidence for the RA's early diagnosis, therapy and prevention.Methods: 164 patients with Rheumatoid arthritis (RA) and 101 healthy controls from Northwest China have been genotyped for IL-1RN 86bp VNTR,IL-1B-511 and IL-1B+3954 by using polymerase chain reaction and polymerase chain reaction-restriction fragment length polymorphism. The analysis of their genotype and allele distributions and haplotype construction were performed.Results: The genetype and allele distributions of IL-1B+3954 polymorphisms were signficantly difference in RA patients compared with the controls (P=0.001 ; P=0.001,respectively). A significant difference was also observed in the haplotype of IL-1RN 1/ IL-1B -511C/ IL-1B+3954T between RA and control groups(P=0.024,OR=5.028,95% =1.06-23.79). No signficantly differences were found in IL-1B-511 and IL-1RN between RA and control groups.Conclusions: This study shows a strong association between the IL-1B+3954 genetic polymorphisms and RA among northwest Chinese population. It indicates that the genetic polymorphism contribute to RA pathogenesis in the cohort. Therefore, this finding could provide the evidence for RA's prevention, supervise and early diagnosis.