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Susscrota Domestica Arteriovenous Malformation Of Brain Of Model Establishment And Correlation Study

Posted on:2008-04-24Degree:MasterType:Thesis
Country:ChinaCandidate:X B NingFull Text:PDF
GTID:2144360215452450Subject:Surgery
Abstract/Summary:PDF Full Text Request
Objctive: The discussion take the domestic pig as the experimental object, The method tallies which through the microsurgery surgery blood vessel establishes one kind new, economical, the simple AVM model and conducts the research to its correlation aspect. After the model manufactures successfully, The blood flow from one side ascending pharyngeal artery (feeding artery) to the basalis of blood capillary rete (rete mirabile, RM). The drainage enters another one side to ascending pharyngeal artery, the common carotid arteries, anastomotic stoma, the internal jugular vein (draining vein). After operation acute stage, the subacute time and the chronic angiography proved whether the model does exist. It provides the basis for embolism material experiment opportunity.Method: Selects the health domestic pigs (five Yuan hybrid pigs) 8 heads, 3-4 age of the month, 30-45KG, the sex does not limit. The experimental group 8 domestic pigs stochastic serial number is 1-8, micrurgy establishes the AVM model. The 2 examples are compared to one side the common carotid arteries angiography at the surgery before 3 day.Intermuscular injection fast dormancy new II 0.3ml/kg. After 3-5 minute the pig consciousness to be faint and eyelash reflection to vanish on supine decubitus fixed surgery table. 8 domestic pigs use the latero-trachea the longitudinal incision, length6-10cm. Four examples (1-4) right the latero-trachea the longitudinal incision. Four examples (5-8) left side of the latero-trachea the longitudinal incision. Cuts open the skin, hypodermic fascia. We touch the pulsation of the common carotid arteries from sternomastoid muscle wall, use the self-restraint pulls the hook to pull open the sternomastoid muscle and exposes the common carotid arteries sufficiently, find the internal jugular vein partner line in the common carotid arteries lateral, separate section of the common carotid arteries and the internal jugular vein separately, eliminate the vagina vasorum, ligate the common carotid arteries proximal part and the internal jugular vein far heart part, non-damages the blood vessel clamps shuts the common carotid arteries far heart part and the internal jugular vein proximal part.We select 7-0 non-damage nylon suture line interrupted suture the common carotid arteries far heart part and the internal jugular vein proximal part. We take angiography to opposite side the common carotid arteries separately at the surgery latter 3 day, 1 week and 1 month, and carry on the 2 examples comparison to one side the common carotid arteries angiography at the surgery before 3 day. To observe whether model establishes succeeds and whether experimental animal's response and complication.Result:1. The experimental group 8 surgery survives completely, non-margin infection phenomenon. Non- hemiparalysis phenomenon. 2. The comparison group of two-sided the common carotid arteries radiography can only see radiography side half the basalis of blood capillary rete. We take angiography to opposite side the common carotid arteries separately at the surgery latter 3 day, 1 week and 1 month, the obvious blood stream after the surgery opposite side ascending pharyngeal artery to the two-sided skull bottom capillaries net, and the drainage obtaining operation side ascending pharyngeal artery or the internal maxillary artery.3. The experimental group opposite side the common carotid artery radiography after surgery 3 day have seen the blood stream to ascending pharyngeal artery to the two-sided skull bottom capillaries net, and the drainage obtaining operation with the side ascending pharyngeal artery, the process ascending pharyngeal artery distinction drainage to enterâ‘ the common carotid arteries and the internal jugular vein.â‘¡t he external carotid artery.4. After 1 week opposite side the common carotid arteries radiography, 6 examples result is same with after surgery 3 day. Another 1 example is seen the blood stream to ascending pharyngeal artery to the two-sided skull bottom capillaries net, to RA, AA drainage enters in the internal maxillary artery. The surgery side the common carotid artery and the internal jugular vein disappear.5. The experimental group surgery latter month good opposite side the common carotid arteries radiography, 7 example obvious blood liquid flow swallows completely after the surgery opposite side rises the artery to the two-sided skull bottom capillaries net, and after RA, the AA drainage enters in the jaw the artery.6. Four examples which use right flank tracheae the vertical margin surgery operate easily, right flank the common carotid arteries and the internal jugular vein. near parallel partner line. 4 examples which use left side tracheae the vertical margin surgery operate slightly difficult, because left side the common carotid arteries and the internal jugular vein. assume"å…«"the character partner line.7. To discover the sternomastoid muscle thick extremely, outside the external carotid artery shows shallow, the inside the common carotid artery shows deep, the there are far from above 2 centimeters. If the two end-end anastomosis or the side-side anastomosis needs to shut off the sternomastoid muscle, the surgery damages hardly, and anastomosis tensity to be hard, the surgery is difficult.8. Animal appears when the feed chews not nimbly, the surgery side waters at the mouth, and has agitated the phenomenon, gnaws nips the manger and the hard stockade, the above phenomenon vanishes after 8-10 day. Only No.5 pig vanish above symptoms in operation 5 days later.Conclusion:1. To apply domestic pigs interrupted suture the common carotid arteries far heart part and the internal jugular vein proximal part method establishes the AVM model is a kind of expense economy, the operation simple, the duplication strong empirical method. 2. The experimental group adopt surgery opposite side the common carotid arteries radiography separately at the surgery 3 day, 1 week and 1 month later. The obvious blood stream from the common carotid artery to ascending pharyngeal artery to the two-sided skull bottom capillaries net, and the drainage obtaining operation with the side ascending pharyngeal artery and(or)the internal maxillary artery.3. Anastomosis stomata close after 1 week. We consider about being concerned with vascular anastomosis technique, no anticoagulation after operation, blood volume insufficiency and the animal moves restlessly.4. The internal maxillary artery become draining vein after anastomosis stomata close.5. The AVM model can be utilized to study embolism efficacy of materials, to simulate AVM morphology and hemodynamics, to train neuroradiology docters.
Keywords/Search Tags:arteriovenous malformation of brain, rete mirabile, model, vascular anastomosis
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