Effects Of PCIA In Immune Function Of Patients With Malignant Tumor

Objective: To investigate the effect of postoperative continuous venous injection analgesia (PCIA) on T Lymphocytic cell subpopulation, NK Cell, Interleukin–2 (IL-2) and Interleukin-6 (IL-6) in patients with malignant tumor.Methods: Fifty patients with malignant tumor were randomly divided into two groups: group I was postoperative continuous venous injection analgesia (n=25);group II was control group (n=25). VAS scores were measured at 5h and 24h after operation respectively. Blood samples were taken before anesthesia, operation end and postoperative 24h, 48h, 168h for the determination of T Lymphocytic cell subpopulation (CD3, CD4, CD8, CD4/D8), NK cell, Interleukin-2 (IL-2) and Intherkukin-6(IL-6).Results: VAS scores of group I were markedly lower than that of groupⅡin postoperative 5h and 24h (P<0.05). Before anesthesia, there was no significant difference in T Lymphocytic cell subpopulation (CD3, CD4, CD8, CD4/D8), NK cell, IL-2 and IL-6 between two groups (P>0.05). The level of CD3, CD4, CD8 and NK cell were all decreased at operation end and postoperative 24h, 48h in two groups compared with baseline value. But at postoperative 24h, 48h, the level of CD3, CD4, CD8 and NK cell in group I was increased compared with group II (P<0.05). Compare with baseline value, IL-2 was decreased at operation end and postoperative 24h, 48h in group I, while IL-6 was increased. The tendency was the same in group II. IL-2 in group I was higher than that of group II at postoperative 24h, 48h, while IL-6 in group I was lower than that of group II (p<0.05).Conclusion: Postoperative continuous venous injection analgesia (PCIA) not only relief pain but also protect immune function of patients. This might be beneficial to the patients with malignant tumor.