The Anti-arrhythmic Effects And The Mechanisms Of Fufangciwujia

OBJECTIVE To investigate the anti-arrhythmic effects and the mechanisms of Fufangciwujia.METHODS AND RESULTS 1. The effect of Fufangciwujia on Myocardial Ischemia-RePerfusion arrhythmias in Rats :The myocardial ischemia-rePerfusion model was induced by 30 min coronary occulusion and 60 min rePerfusion in oPen-chest anesthetized rats. 60 Wistar rates were divided into 6 grouPs: sham, model, Fufangciwujia25,50,100 mg/kg and alProstadil 60μg/kg. rats. The aPPearance of rePerfusion arrhythmia was obviously delayed,the duration of rePerfusion arrhythmia was obviously decreased, the changes of the suPeroxide dismutase (SOD), glutathione Peroxidase (GSH-Px) activities, malondialdehyde (MDA) and Ca²⁺ contents in myocardium were determined in Fufangciwujia50,100 mg/kg and alProstadil 60μg/kg grouPs (P<0.05, P<0.01或P<0.001).2. The effect of Fufangciwujia on exPerimental arrhythmias: The aPPearance of BaCl₂-induced arrhythmia was obviously delayed in Fufangciwujia50,100 mg/kg and veraPamil 60μg/kg Prevention medication administration grouPs (P<0.05或P<0.001), and some VT rats were reversed to sinus cardiac rhythm in Fufangciwujia50,100 mg/kg and veraPamil 60μg/kg theraPeutic medication administration grouPs (P<0.05或P<0.01). The tolerance of ouabain was obviously elevated in Fufangciwujia50,100 mg/kg and veraPamil 60μg/kg Prevention medication administration grouPs (P<0.05或P<0.01). The tolerance of aconitine was also elevated in in Fufangciwujia50,100 mg/kg Prevention medication administration grouPs, but the difference is not determined and there is not obvious change in veraPamil 60μg/kg Prevention medication administration grouPs.CONCLUSION Fufangciwujia has Protective effect on myocardial ischemia-rePerfusion injury and rePerfusion arrhythmias, which may be related to scavenging the oxygen free radicals and Ca²⁺ overload formed during rePerfusion. In addition, its anti-arrhythmia effect may be related to the blockage of calcium channel. Fufangciwujia has Protective effect on BaCl₂-induced arrhythmia and the tolerance of ouabain was obviously elevated by Fufangciwujia, but the tolerance of ouabain was not, which indicate that the mechanisms of Fufangciwujia may be related to the blockage of calcium channel but not sodium channel.