Analysis On The High Risk Factors Of Axillary Lymph Node Metastasis In Patients With Breast Cancer

Axillary lymph node dissection is the major part of the breast cancer operation, the purpose of the operation is to cut the lymph nodes which had metastatic, to definite stages, to estimate prognosis, to make a decision of combined therapeutic regimen after operation, but the postoperative complications such as lymphedema of upper limb,functional disturbance are the tough problems of clinical therapy at present. There may be to bring about the unessential damages if take the axillary lymph node dissection blind, at the same time we can know from the documents to predict the axillary lymph node metastasis the avoid the axillary lymph node dissection. The most research of axillary lymph node metastasis is still limited in the factors of relapse and survival, but now we emphasize study the factors of axillary lymph node metastasis and stage of N. Trough this to expect help the doctors decide the state of ALNM accurating, become a significance to guide the doctors estimating prognosis, choosing a correct way of adjunctive therapy after operation.Materials and methods: Collect the clinical data of 252 breast cancer patients in our hospital from 2000 to 2004 by the computer records conservancy system. There clinical features including age, menopausal status, number of pregnancies, age of menarche, tumor size and location, pathological type, hormonal receptor status, distant place metastasis, duration before diagnosis and axillary lymph node status were retrospectively analyzed. At the same time compared the methods of check the state of axillary lymph node by physical and pathology.Result: 1. There is 47.22 percent of 252 cases without axillary lymph node metastasis and 52.78 percent of cases with axillary lymph node metastasis in breast cancer patients. Among the lymphnode-positive cases, there are 71 cases with pN+≤3, 51 cases with 30.05). 5. The factors such as tumor size, pathological type influenced the stage of N by spearman rank correlation analysis (P<0.05). The number of lymph node metastasis would increase with tumor size increasing, poor pathological type. 6. The factors such as the age of onset, tumor size, pathological type influenced the axillary lymph node metastasis bymultivariate analysis (P<0.05). The older of the patients, the lymph node metastasis rate is fall-off. The lymph node metastasis rate raised with tumor size increasing, poor pathological type. Among the factors, the most significant is pathological type, tumor size and age of onset by turns.Conclusion: 1. There is relationship between axillary lymph node metastasis and age of onset, tumor size and location, pathological type, age of menarche. The most significant is pathological type, tumor size and age of onset by turns. 2. The factors such as tumor size, pathological type influenced the stage of N. 3. The axillary lymph node metastasis rate of infiltrating lobular carcinoma is the tallest of all breast cancer (80.65%), and the influence is the largest. 4. The difference express condition of ER, PR in breast cancer patients do not effect the axillary lymph node metastasis, but influence the proliferation of cancer cell.