The Anticoagulation Effect Of Injection Of Ginkgo Bibola Leaves Extract On Rabbit

Objective to investigate the anticoagulation effect of extract of ginkgo bibola leaves (Egb) on rabbits. Methods seventy two rabbits were divided randomly into three groups(n=24 in each group). Warfarin was not given in group 1. Warfarin was given in group 2 to achieve 1.8-3.7 times INR of normal rabbits. Warfarin was given in group 3 to achieve 3.7-6.0 times INR of normal rabbits. The rabbits of each group were further divided into the Egb group(0.3ml/kg, 1.5ml/kg, 3ml/kg) and the control group (6 in each group). Intravenous infusion of 0.3ml/kg NS was given to the rabbits in control group, and intravenous infusion of 0.3ml/kg, 1.5ml/kg, 3ml/kg Egb761 were given to the rabbits in Egb group. After 1.5 hour of injection on the seventh day, the blood samples were collected , and PLT, PT, APTT, PF3aT were examed. Results Egb761 has no effect on PLT, PT, APTT of normal rabbits and anticoagulant rabbits(p>0.05), while it has effect on PF3aT(p<0.05), The effect on the long INR group are bigger than the shorter INR group. Egb761 can cause coagulation disorder by affecting platelet factor 3 andhinder the activation of platelet Egb761 also can positively cooperate with warfarin and might lead to severe coagulation disorder. Conclusion Injection of extracts of ginkgo bibola leaves can affect anticoagulation therapy.