The Effect Of Depression On HsCRP Value In The Coronary Artery Disease Patients

[Background] :Depressive symptoms are common in patients with coronary artery disease (CAD), and are associated with increased cardiac risk. Until today there has been no clear etiological model to explain the interaction of depressive disorders and cardiac risk parameters. The possible pathophysiological mechanisms are inflammatory processes and immune responce, dysfunctional endothelium of the arteries and the decrease of the cardiac autonomic innervation evidence. In most exist study, depression can elevate some cytokines and inflammators of CAD patients, such as hsCRP, IL-6, and so on.HsCRP (hyper sensitive C-reactive protine) is the most sensitive acute phase reactive protine, which can activate complement, promote englobement and accommodate immune system. It has been widely used in now science.Today many study had shown that there had increased hsCRP value ineither coronary artery disease patients or depression patients. But there had little data about the hsCRP value in patients with both disease.[Aim] :We study the hsCRP values in depression patients(group B), coronary artery disease patients(group C) and patients with both disease(group D) contrast to normal people(group A), try to understand the effect of depression on hsCRP values in the coronary artery disease patients.[Method] :First, we collect clinical features and hsCRP values of all four groups(group A, B, C, D) in SIR RUN RUN SHAW HOSPITAL from July 2006 to February 2007. Second, we calculate the depression prevalence in coronary artery disease patients. Third, we account the mean hsCRP value and compare all statistic significance of every two groups in four groups.[Result] :We collected 48 coronary artery disease patients, 8 (16.7%) patients accompanied with depression. The mean hsCRP values decern in four groups are 0.24 ±0.25(group A), 0.18±031 (group B), 0.77±0.98(group C), 1.77±2.63(group D) mg/l. And we found that the mean hsCRP value in coronary artery disease patients(group C) and patients with both disease(group D) are evidently higher than normal people(group A) (p<0.05) , while in depression patients(group B) is similar to normal people(group A)(p>0.05). Beside that, the mean hsCRP value in patients with both disease(group D) are evidently higher than coronary artery disease patients(group C) (p<0.05).[Conclusion] :We found that the coronary artery disease patients had more higherhsCRP value than normal people and depression patients; patients with both coronary artery disease and depression had the most higher hsCRP value. We hypothesis that depression may elevate the hsCRP value in coronary artery disease patients. Of course it need more profounding study. All us should reconstruction the evaluation and therapy of the coronary artery disease patients with depression.