Research Of Measurement Of The Total Attenuation Coefficient Of Biological Tissue With Optical Coherence Tomography

The distribution of light in biological tissue is one of the major concerns in the clinical application of laser medicine. Theoretically, as long as we know the optical properties of biological tissue in certain wavelength, we can determine the distribution of light in biological tissue by the radiative transport equation. Regrettably, the optical properties of biological tissue are still little to be known. Therefore, it is necessary to accurately measure the optical properties of biological tissue, especially the human's.The main work of this thesis is as follows:1. We obtain the basic idea of measurement of optical properties of biological tissue, under theoretically researching of interaction between light and biological tissue, and several measuring methods of optical properties of biological tissue based on approximate solutions of radiative transport equation, by reading up a lot of original and recent foreign literatures and periodicals.2. We have got a method, basically meeting our requirements, of simulation of OCT by Monte Carlo modeling, which is achieved by revised based on the MCML algorithm, through our in-depth study on it.3. We have gained the total attenuation coefficient of intralipid and skin on the tip of human index finger in vivo by measuring them with the OCT experimental device which is designed and set up by ourselves with the reference of fiber-OCT.The major conclusions of our work are as follows:Known from the results of two different methods of measurement of the optical properties of intralipid injection in practical experiment and simulation of Monte Carlo respectively, the experimental and simulation results is consistent. Moreover, we have measured the total attenuation coefficient of the skin of index finger by adopting the first-order multiple-scattering theory with OCT technology, whose values is basically consistent with the published data, which display the potential of noninvasive measurement of optical properties of biological tissue with OCT technology.