The Effects Of Stress On Related Hormones Of Neuroendocrine In Type 2 Diabetic Patients

Objective:To investigate the effects of stress on glycemia and lipidemia as well as the serum levels of neuroendocrine hormones (cortisol, GH, FSH, LH, T and E2 ) and further explore the mechanisms of worsened insulin resistance during severe stress in type 2 diabetic patients.Methods:Patients were divided into stress group and control group according to stress or stressless state. Plasma levels of glucose, insulin as well as the serum levels of cortisol, GH, FSH, LH, T, E2 , cholesterol and triglycerides were measured by means of glucose oxidase assay, chemoillumioimmunologic assay and biochemical assay technique, respectively. Insulin resistance index was measured by Homa model index.Results:The plasma levels of fasting glucose, fasting insulin and Homa-IR in stress group were higher than those of control group (P<0.05). There were no statistical significant difference in the serum levels of cholesterol and triglycerides to be observed between stress and control group(P>0.1). The serum levels of cortisol and GH increased signficantly, otherwise, the serum levels of FSH, LH, T and E2 decreased significantly(P<0.05)in the stress group compared with the control group. The Homa-IR index was positive correlation with cortisol and GH and negative correlation with T and E2(P<0.05). The correlation coefficient were 0.473, 0.462,-0.435, -0.424 , respectively.Conclusion: Stress further worsened the homeostasis of glycemia and increased insulin resistance of type 2 diabetic patients accompany with disorder of neuroendocrine hormones.the mechanisms of worsened insulin resistance probably related to the disorder of neuroendocrine hormone during severe stress in diabetes.