Indices Of Clinical Monitoring In Disease Activity Of Inflammatory Bowel Disease

Objective: To evaluate the monitoring action of the expression myeloperoxidase (MPO) and superoxide dismutase (SOD) activity in the active inflammatory bowel disease (IBD).Methods: Fifteen active IBD patients (including 10 active ulcerative colitis(UC) patients and 5 active crohn's disease(CD) patients.), 15 inactive IBD patients (including 10 inactive UC patients and 5 inactive CD patients.), 15 non-IBD inflammation patients and 12 control patients were selected. Pathology ,MPO and SOD activity were determined on the endoscopic biopsy specimens of all patients. Results: Bowel mucosal MPO activity of active IBD patients, inactive IBD patients, and non-IBD inflammation patients are higher than that of control patients, (3.55 ± 0.38, 2.28 ± 0.30 and 2.60 ±0.27)U/g tissue vs (1.52 ± 0.24)U/g tissue (P<0.01). Bowel mucosal SOD activity are lowel than that of control patients,(104.58±18.91, 170.91 ± 13.57, and 166.55 ±16.25)U/mg protein vs (212.44±14.22)U/mg protein (P<0.01). Bowl mucosal MPO activity of active IBD patients is also higher than that of inactive and non-IBD inflammation patients (P<0.01); while SOD activity is lower than them (P<0.01). Conclusion : Bowel mucosal MPO and SOD activity could be used as 2 indices monitoring the activity of IBD.