Prognosis Of The Basal Follicle-Stimulating Hormone On Ovarian Reserve

With increasing female age, the probability of pregnancy declines. This decline in fertility is most probably due to diminishing ovarian reserve, that is the quantity and quality of the follicles in the ovary. The basal follicle-stimulating hormone (bFSH, blood FSH levels in menstrual cycle day 2 or day 3) is the most common marker to predict ovarian reserve. Those patients with elevated FSH levels were shown to have lower pregnancy rates after in vitro fertilization (IVF) It is important to evaluate ovarian reserve before we start treatment for infertility women with IVF cycle. Recently, some debate about the real clinical value of measuring bFSH before IVF has arisen because investigators have found that moderately elevated bFSH levels were not predictive of IVF outcome, especially in younger women . In order to find out the truth, we start this research.Objective: To access the predictive value of the bFSH measurement in predicting ovarian reserve in FVT.Methods: Subjects, who were treated with IVF, were selected in Women's Hospital School of Medicine Zhejiang Univercity in 2004. The following information was collected: bFSH levels, controlled ovarian stimulation (COS) days, number of oocytes collected, number of good embryos, the E₂ levels in the human chorionic gonadotropin (hCG) injection days, and the results of the patients. From these patients, we selected 374 patients who fulfilled the following inclusion criteria: no PCOS, no ovarian operation, two oviducts present, regular menstrual cycle, and only GnRH-a long protocol of COS. The patients were divided into 3 groups (group 1, 2 and 3) by bFSH levels (...