Clinical Significance Of Hs-CRP,BNP Level In Patients With ST-segment Elevation Acute Myocardial Infarction

Background: The studies show AMI were almost resulted from atherosclerosis and thrombogenesis in the coronary artery, the advance made in study of atherosclerosis in recent decades have led to its understanding as an inflammatory disease. So the determination of the levels of inflammatory markers is useful in evaluating risk stratification and prognisis of patients with AMI.CRP is a kind of sensitive inflammatory marker, and have been widely used. How the CRP level change in patients with AMI were poorly studied. In addition,the BNP have been thought to be well defined as a biomarker of ventricular function, the associatied measure of CRP and BNP may be preferable for evaluation of prognosis.Objective: To observe the levels of plasma c-reactive protein(CRP)and brain natriuretic peptide(BNP)in patient with first ST-elevated acute myocardial infarction(AMI). To analyze the clinical significance of CRP,BNP levels for inchoate prognostic of AMI.Methods: The study enrolled 80 patients who had first ST-segment elevation acute myocardial infarction. All patients were divided into three groups: the primary PCI group,delayed PCI group and medicinal treatment group .In all patients the concentrations of hs-CRP were measured at 6h,24h,36h,48h,60h and 12d. BNP were measured at 12d after AMI. Left ventricular function and ventricular wall thinning ratio were evaluated by echocardiography from 12 days to 14 days after AMI.Result: The plasma CRP concentration show dynamic variation with time in all patients. The maximum level and peak time of CRP is significantly different between the early reperfusion groups and non-early reperfusion. In primary PCI group the maximum level were lower and the peak time wereearlier. BNP were lower comparing with non-primary PCI group.Correlation analysis show: There were positive relationship between CRP and BNP, CK-MB,WMSI. There were negative relationship between CRP and LVEF.Conclusion: The associatied measure of CRP and BNP could preferably evaluate the inchoate prognostic of AMI. CRP might be an useful index of successful reperfusion and predict the stability of infarction related lesion.