Study On The Synthesis Of Novel Silicone Anticoagulantive Coating Materials

In this reaserch work, we had basic reaserch on anticoagulant material which is one kind of polymeric biomaterials. The development of biomedical materials will greatly impulse technology innovation . But when many synthetic macromolecule contact with blood , there would be a serial of reaction in contacting such as coagulation on the interface. Thus it limit macromolecule application in contacting with blood. So how to improve the antithrombogenicity of the biomaterials is always one of main reaserch and development content. Silicone material has the characteristic of innocuous, insipid, good anticoagulantion, good biocompatibility, bioinertia, good air-permeability because of unique chemical structure. Silicone material is always the reaserch focus and development in the field of biomaterial.Hydrosilylation is one of the most important synthetic reactions for the formation of carbon-silicon bonds on a laboratory and an industrial scale. Many organic silicon compounds can be synthesized with hydrosilylation reactions. The hydrosilylation of alkenes results in alkylsilanes that are versatile starting materials for natural products and polymers. PHMS with n-butyl methacrylate were prepared by the hydrosilylation reaction, using Pd as the catalyst, improving adhesive strength on the surface of medical polymers.The structure of the grafted silicone was analyzed by FTIRS and ~1H-NMR. The surface and constitution of the modified PVC were determined by X-ray photoelectron spectroscopy (XPS). The contact angle of grafted polymer films was measured by a contact angle geniometer. Blood Routine Examination, Static Antithrombogenic Test, Measuring Oxygen Saturation with venous blood were conducted to evaluate the blood compatibility of materials.The FTIR, ~1H-NMR and XPS indicated that n-butyl methacrylate has been grafted to the chain of PHMS, and the grafted polymer can adhesive on the surface of PVC. The SEM and the results of Blood Routine Examination indicated that the grafted...