The Value Of Evaluating Of The Cerebrovascular Reserve Capability By Combining The MRI Perfusion With An Acetazolamide Challenge

Object:To research the feasibility of cerebrovascular reserve capability by combining the MRI perfusion with an acetazolamide challenge and evaluate the clinical meaning to patients with cerebral infarction and hypertension.Materials and methods:32 patients and volunteers were divided into three groups: cerebral infarction group, hypertension group, and control group. Two MRI examinations before and after oral administration of acetazolamide were performed to each group. MR and PWI examination were performed by 1.5 T GE Signa MR scanner. PWI imaging was processed by the Functool 2.0 work software. Then we counted the CRC of none stroke area in infarction group, and the CRC of super frontal gyrus, super tempo gyrus, caput nuclei caudate, lenticular, thalamus, and cuneus in hypertension group and control group. CRC was calculated by the formula: CRC (%)=[(acetazolamide challenge rCBF-resting rCBF)/resting rCBF] 100. Analysis was performed with SPSS13.0 soft ware.Results:1. Comparing CRC average value(14.94% and 15.97%) in the symmetry areas that away from the stroke lesions, we found that no statistical differences in both hemispheres2. In view of MTT, rCBV and rCBF of ROI in hypertension group, there were no statistical differences before and after ACZ challenge.(p>0.05)3. MTT of ROI were shortened after ACZ challenge in control group(p<0.05), rCBV and rCBF were increased after ACZ challenge in control group(p<0.05)4. Comparing CRC of ROI in hypertension group (5.5-27.8%) with control group's (34-56.1%), we found that CRC in hypertension group was manifestly decreased (p<0.05).Conclusions:1 PWI can be used to observe the by pass circulation and reperfusion condition in...