The Correlation Of Symptomatic Stenosis In Middle Cerebral Artery, Basilar Artery To Stroke In Progression

Objectives:Using transcranial Doppler (TCD) sonography as the method of evaluating artery stenosis, to observe the correlations of symptomatic stenosis in middle cerebral artery (MCA) and basilar artery (BA) to stroke in progression (SIP).Methods:Patients (164 cases) with acute cerebral infarction in MCA or BA district were involved in this study. Main exclusion criteria: cerebral embolism of cardiac source; total anterior circulation infarction; patients treated with thrombolysis. SIP was diagnosed when neurological deterioration was evident (NIHSS≥3) from 6 hours to 7 days after the onset. MCA and BA stenosis as well as the stenosis grading was evaluated with TCD sonohraphy. The correlations of symptomatic MCA, BA stenosis to SIP were analyzed with SPSS 10.0 software.Results:The incident rate for SIP was 45.73%. 70 cases were symptomatic stenosis, included 40 cases MCA stenosis and 30 cases BA stenosis. The incidence rate of SIP in patients with symptomatic stenosis (57.70%) was much higher than non-intracranial artery stenosis and asymptomatic stenosis (36.60%). Logistic regression analysis showed that symptomatic MCA and BA stenosis(OR=2.560) and female(OR=2.010) were the risk factors of SIP. The incidence rate for SIP in patients with non-intracranial artery stenosis and asymptomatic artery stenosis , mild, moderate and severe artery stenosis were 37.2%, 46.1%,65.2% and 61.9% respectively , which have significant differences. The risk for SIP is highest in moderate symptomatic MCA or BA stenosis, and higher in severe...