The Association Between The EOS, IL-5 In Sputum And Severity Of Bronchial Asthma

OBJECTIVE: To study the dynamic changes of EOS and IL-5 levels before and after ICS treatment in induced sputum samples of the patients with mild to moderate persistent asthma and to evaluate whether it is valuable for asthma control or not.METHODS: Subjects enrolled in were uncontrolled mild to moderate asthmatic individuals according to clinical feature, aged 14-73 years (means 39. 6). They treated with different dosage of ICS and LABA from the foundation of clinical features, PEF, and the previous medicine. The standards of subjects releasing complete is judged by GOAL. When these asthmatics came to a complete remission, they should be evaluated the clinical features, measured the PEF, counted the amount of EOS and detected the concentration of IL-5 in the sputum samples. RESULTS: 45 patients were enrolled in the study, 40 of them subjec ts finished over a half year's follow-up. 38 of 40 received complete remission based on the standard of CINA, 2 patients only received well control after regularly treating by inhaled corticosteroid. The other five subjects dropped off. The clinical features, PEF, the count of EOS and the concentration of the IL-5 of the all asthmatic individuals were improved obviously and there was a significant difference from the results before therapy (P<0. 001). CONCLUSION: 1. Induced sputum with standardized procedures has virtues such as convenience, non-invasion and repeatability. It may be used as a guideline to treat patients with mild to moderate asthma patients and to assess the severity of symptoms. 2. The count of the EOS decreased after the ICS therapy, but the count of EOS was above 3% for some patients after complete releasing. Meanwhile, there was a significant difference between pre-and after-therapy in the concentration of the IL-5. It demonstrated that the concentration of the IL-5 is more sensitive in reflecting the state of the airway inflammation.