Cerebrospinal Fluid Replacement Therapy For Subarachnoid Hemorrhage: A Systematic Review

Objectives To assess the effectiveness and safety of cerebrospinal fluid replacement / permutation therapy for subarachnoid hemorrhage (SAH). Methods The Cochrane systematic review method was used to evaluate the Randomized Controlled Trials (RCT) of cerebrospinal fluid replacement /permutation therapy for SAH. The searching strategy included: The CochraneCentral Register of Controlled Trials ( Issue 4, 2005) , MEDLINE ( 1966 to Nov. 2005) ,EMBASE (1984 to Nov. 2005), the China Biological Medicine Database (1979-2005.11) , the CNKI Database (1979-2005.11) ,the Chinese Stroke Clinical Trials Database (2003-2005.11), the Papers First (OCLC) Database (1993-2005.11), the China Doctor & Master Dissertation Full-text Database (1999-2005.11) ,the Chinese Proceedings of Conference Full-text Database (1999-2005.11) and the reference lists of related articles. Two reviewers independently selected studies, assessed quality of studies and extracted data. The RevMan 4. 2 software was used for statistical analysis. Results We included 60 randomized controlled trials involving 5096 patients. The methodology quality of all the trials was poor. Since the poor outcome and adverse events evaluation of SAH patients was absence among...