A Phase Ⅲ Study Of Para-toluenesulfonamide Administered Intratumorally And Peritumorally To Patients With Oral Malignant Tumor

The worldwide number of cancer case estimated in the year 2000 was approximately 5.3 million for male and over 2.5 million for female.In China,the number is also on the rise.As for the treatment of tumor,the combined and sequential therapy is advocated.And in this serial therapy,chemical therapy plays an important role.The local chemical therapy,because of its low toxic effect and high local concentration's becoming an essential supplement.Objective: 14 patients were administrated intratumorally and peritumorally with para-toluenesulfonamide(PTS) to determine the efficacy and safety of PTS.Mathod:14 patients with oral malignant tumor were treated by PTS administrated intratumorally and peritumorally.The efficacy was estimated by clinic efficacy and histopathological observation.The safety of PTS was estimated by biopsy,lab examination,ECOG and...