The Hemodynamic Effect Of Adenosine Triphosphate In Patients With Pulmonary Hypertension Secondary To Congenital Heart Disease

[ Background ] Pulmonary hypertension is the most common complication secondary to left-to-right congenital heart disease and rheumatic heart disease. It's the main factor which determines the operation indication, operation opportunity and operation risk. However, commonly used selective pulmonary vasodilators have some side effects. Adenosine triphosphate(ATP), as one of ideal pulmonary vasodilators, has been used in the treatment of postoperative pulmonary hypertension secondary to congenital heart disease. But the treatment result and the dosage range of ATP in postoperative pulmonary hypertension secondary to congenital heart disease are not clear.[ Object] To validate the hemodynamic effects and high selectivity of ATP as a pulmonary vasodilator. Analyze the changes of pulmonary and systemic circulation under the different doses of ATP and the reactivity of pulmonary hypertension at different degree to the ATP's curative effect. Hoping to find out the dosage range of ATP, in which ATP has the best selective pulmonary vasodilating effect, to guide the further clinical applications.[ Methods ] Choose 15 in-patients with pulmonary hypertension secondary to congenital heart disease. Put in Swan-Ganz catheter...