Study On P50 Auditory Evoked Potential In Rat Model Of Alzheimer's Disease By Transected Fimbria-fornix

Objective Through auditory evoked potential P50, we study the changes in rat model of Alzheimer's disease by transecting bilateral fimbria-fornix. To investigate the relation of Alzheimer's disease and auditory evoked potential P50. It is essential to diagnosis Alzheimer's disease in clinical early stage.Methods Twenty four health female SD rats(200～300g) were randomly divided into three groups. Every group includes 8 animals. The model was made by transecting bilateral fimbria-fornix and proved successful by Morris water maze. All rats were embedded by electrode under anaesthesia. Auditory evoked potential P50 were recorded by the conditioning/testing paradigm presented with auditory double clicks stimuli. Comparison of the responses to auditory evoked potential was made among the model and the normal and he control group. Amplitude of condition P50, amplitude of test P50, test/condition rate and ranges of S2-S1 were calculated. The data were processed with the SPSS statistical method.Results 1. The rat model was certificated by Morris Water Maze. 2. It is non-difference to compare of normal group and control group; In the rat model group, the result showed: ①The amplitude of condition P50 response were (9.67±3.77 ). They were significantly lower than the amplitude(17.04 ± 5.32) of the normal group(P<0.01)and the amplitude (21.01±2.86) of the control group; ②The test/condition rate were (0.92 ± 0.42). They were increase significantly than the normal group(0.39±0.16)(p<0.01) and the control group(0.25±0.18); 3.The ranges of S2-S1 were (2.89±2.61). They were significantly diminished compared with the normal(10.85±4.24) and the control group(15.26±4.07).