Studies On Ginsenoside C-K Intravenous Emulsion

In this article, we had studied on the formulation and preparation technique of ginsenoside C-K intravenous emulsion and evaluated its physico-chemical stabilities,pharmacodynamics and safety.Refined soybean phospholipid and F-68 were chose as emulsifiers when the judgemental criterion was interfacial tension. According with the particle size distribution (or Ke )of emulsion we found the best proportion of the two emulsifiers. The pH values and the condition of steam sterilization were confirmed referring to the zeta potential. The preparation techniques were selected by orthogonal method and had a good result. The C-K intravenous emulsion had steady physico-chemical properties after storing in accelerative test for 6 months and in influencing factor test for 10 days . All phases of C-K intravenous emulsion were separated by overspeed centrifuge and were determined by HPLC. Most of the C-K in the intravenous emulsion were in the interfacial phase and a small quantity of C-K distributed in water phase and oil phase. The release kinetics of C-K emulsion and solution in vitro complied with first order model. C-K intravenous emulsion and solution could effectively restrain the growth of H₂₂ liver cancer, lewis lung cancer, U₁₄ cervices cancer and B₁₆ melanin tumour at the dosage of 15mg/kg and 30mg/kg respectively. In contrast to the solution ,the C-K intravenous emulsion had better effect on antitumour. Using S₁₈₀ ascites tumour mice we studied the effect of C-K intravenous emulsion and solution on the life-timeof mice.The result displayed that the intravenous emulsion could prolong the...