Effect Of Hepatocyte Growth Factor (HGF) On Morphology And Enzymic Histochemistry Of Disused Muscular Atrophy

Limb immobilization is the main treating method to joint injury, but it will cause adverse effects to adjacent normal tissues while protecting damaged tissues. Study shows immobilization may bring change to muscle in physiology, biochemistry and biomechanics aspects, which leads to deterioration of its function. Disused muscular atrophy is an usual side effect and urgent problem in orthopedics.Hepatocyte growth factor (HGF) was first discovered and named as HGF by NaKamura in 1984 in serum from partially hepatectomized rat, which can stimulate growth of primary cultured hepatocytes and liver-sourced factors. Study shows HGF is a multi-functional cytokine and it secreted in many cells. HGF can promote angiopoiesis, nourish the nerve and promote cell proliferation and differentiation. In this study we use HGF as protector to observe its effects to disused muscular atrophy. Objective:Observing preventing and treating effects of HGF to morphology and enzymohistochemistry in disused muscular atrophy. Methods:24 male Wistar rats were randomly divided into blank group, control group and experimental group with 8 rats in each group. Disused muscular atrophy model was...